All things being equal (core design,drilling layout, speed, revs, entry angle, axis tilt, etc...) the 16 lb would have less tendency to deflect off the pins and could cause more pin mixing, but by the same token the 16 lb ball also has to overcome a greater amount of inertia to make that turn into the proper entry angle. That would require more effort on the part of the bowler so ther is a trade off. Personally, I went to 15 lbs due to rotator cuff issues and 14 lbs for my spare ball and my scores are better than when I threw a 16 lb ball. If I had the physical ability to throw a 16 lb ball and create the same conditions as I do currently would my score improve? Maybe but I don't see it making a huge difference, and it's certainly not worth ruining my shoulder over. But as with all things, YMMV.
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